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Efficient Reduction of Esters to Aldehydes through Iridium‐Catalyzed Hydrosilylation
Author(s) -
Cheng Chen,
Brookhart Maurice
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205154
Subject(s) - hydrosilylation , iridium , catalysis , reduction (mathematics) , chemistry , organic chemistry , combinatorial chemistry , mathematics , geometry
Trumping DIBALH : A new method for reduction of esters to aldehydes through silyl acetal intermediates involves a single‐step hydrosilylation catalyzed by a readily available iridium complex, [{Ir(coe) 2 Cl} 2 ] (see scheme; coe=cyclooctene). The low catalyst loading, mild reaction conditions, high conversions, and broad substrate scope make this method a superior alternative to ester reduction using DIBALH.