Metal‐Free Oxidation/C(sp 3 )H Functionalization of Unactivated Alkynes Using Pyridine‐ N ‐Oxide as the External Oxidant | Zendy

Chen DianFeng | Zendy; Han ZhiYong | Zendy; He YuPing | Zendy; Yu Jie | Zendy; Gong LiuZhu | Zendy

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Metal‐Free Oxidation/C(sp 3 )H Functionalization of Unactivated Alkynes Using Pyridine‐ N ‐Oxide as the External Oxidant

Author(s) -

Chen DianFeng,

Han ZhiYong,

He YuPing,

Yu Jie,

Gong LiuZhu

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205062

Subject(s) - surface modification , metal , oxide , pyridine , chemistry , aryl , inorganic chemistry , medicinal chemistry , organic chemistry , alkyl

Externally yours : 2,3‐Dihydroquinolin‐4(1 H )‐ones are obtained in moderate to good yields (40–84 %, see scheme) in a metal‐free oxidation/C(sp 3 )H functionalization of unactivated aryl alkynes. 2,6‐Dichloropyridine‐ N ‐oxide is used as an external oxidant. In the reaction, a Brønsted acid, not a metal, plays a key role in the triple CC bond activation.

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