Premium
Metal‐Free Oxidation/C(sp 3 )H Functionalization of Unactivated Alkynes Using Pyridine‐ N ‐Oxide as the External Oxidant
Author(s) -
Chen DianFeng,
Han ZhiYong,
He YuPing,
Yu Jie,
Gong LiuZhu
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205062
Subject(s) - surface modification , metal , oxide , pyridine , chemistry , aryl , inorganic chemistry , medicinal chemistry , organic chemistry , alkyl
Externally yours : 2,3‐Dihydroquinolin‐4(1 H )‐ones are obtained in moderate to good yields (40–84 %, see scheme) in a metal‐free oxidation/C(sp 3 )H functionalization of unactivated aryl alkynes. 2,6‐Dichloropyridine‐ N ‐oxide is used as an external oxidant. In the reaction, a Brønsted acid, not a metal, plays a key role in the triple CC bond activation.