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A Diversity‐Oriented Approach to Spiroindolines: Post‐Ugi Gold‐Catalyzed Diastereoselective Domino Cyclization
Author(s) -
Modha Sachin G.,
Kumar Amit,
Vachhani Dipak D.,
Jacobs Jeroen,
Sharma Sunil K.,
Parmar Virinder S.,
Van Meervelt Luc,
Van der Eycken Erik V.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205052
Subject(s) - domino , diversity (politics) , computer science , combinatorial chemistry , world wide web , catalysis , information retrieval , chemistry , organic chemistry , political science , law
Caught “Spiro” handed : A diversity‐oriented approach comprised of an Ugi four‐component reaction and a diastereoselective gold(I)‐catalyzed domino cyclization for the generation of complex spiroindolines under mild conditions has been developed. Variously substituted spiroindolines were synthesized in good to excellent yields and with complete diastereoselectivity.