Gold‐Catalyzed Functionalization of Unactivated C(sp 3 )H Bonds by Hydride Transfer Facilitated by Alkynylspirocyclopropanes | Zendy

Barluenga José | Zendy; Sigüeiro Rita | Zendy; Vicente Rubén | Zendy; Ballesteros Alfredo | Zendy; Tomás Miguel | Zendy; Rodríguez Miguel A. | Zendy

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Gold‐Catalyzed Functionalization of Unactivated C(sp 3 )H Bonds by Hydride Transfer Facilitated by Alkynylspirocyclopropanes

Author(s) -

Barluenga José,

Sigüeiro Rita,

Vicente Rubén,

Ballesteros Alfredo,

Tomás Miguel,

Rodríguez Miguel A.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205051

Subject(s) - hydride , catalysis , surface modification , chemistry , cleavage (geology) , combinatorial chemistry , bond cleavage , stereochemistry , medicinal chemistry , polymer chemistry , organic chemistry , materials science , metal , fracture (geology) , composite material

A Golden Gate : Alkynylspirocyclopropanes served as a template for the development of gold‐catalyzed hydride transfer from unactivated C(sp 3 )H bonds to electronically neutral alkynes. A variety of interesting carbocyclic structures can be accessed selectively with the appropriate choice of the reaction conditions. Mechanistic studies support a sequential gold‐catalyzed cleavage of CH and CC bonds.

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