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Gold‐Catalyzed Functionalization of Unactivated C(sp 3 )H Bonds by Hydride Transfer Facilitated by Alkynylspirocyclopropanes
Author(s) -
Barluenga José,
Sigüeiro Rita,
Vicente Rubén,
Ballesteros Alfredo,
Tomás Miguel,
Rodríguez Miguel A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205051
Subject(s) - hydride , catalysis , surface modification , chemistry , cleavage (geology) , combinatorial chemistry , bond cleavage , stereochemistry , medicinal chemistry , polymer chemistry , organic chemistry , materials science , metal , fracture (geology) , composite material
A Golden Gate : Alkynylspirocyclopropanes served as a template for the development of gold‐catalyzed hydride transfer from unactivated C(sp 3 )H bonds to electronically neutral alkynes. A variety of interesting carbocyclic structures can be accessed selectively with the appropriate choice of the reaction conditions. Mechanistic studies support a sequential gold‐catalyzed cleavage of CH and CC bonds.