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Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin
Author(s) -
Liuni Peter,
Jeganathan Araby,
Wilson Derek J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204903
Subject(s) - catalysis , conformational isomerism , chymotrypsin , dynamics (music) , chemistry , selection (genetic algorithm) , enzyme , stereochemistry , computer science , computational biology , biochemistry , biology , psychology , organic chemistry , artificial intelligence , molecule , pedagogy , trypsin
Intensified searching : In enzymes, conformational dynamics are linked to the catalytic reaction coordinate. A novel analytical approach was used to monitor catalysis‐linked dynamics in chymotrypsin, revealing that in some enzymes, catalysis is promoted by intensified, but undirected conformational sampling after substrate binding.