Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin | Zendy

Liuni Peter | Zendy; Jeganathan Araby | Zendy; Wilson Derek J. | Zendy

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Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin

Author(s) -

Liuni Peter,

Jeganathan Araby,

Wilson Derek J.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204903

Subject(s) - catalysis , conformational isomerism , chymotrypsin , dynamics (music) , chemistry , selection (genetic algorithm) , enzyme , stereochemistry , computer science , computational biology , biochemistry , biology , psychology , organic chemistry , artificial intelligence , molecule , pedagogy , trypsin

Intensified searching : In enzymes, conformational dynamics are linked to the catalytic reaction coordinate. A novel analytical approach was used to monitor catalysis‐linked dynamics in chymotrypsin, revealing that in some enzymes, catalysis is promoted by intensified, but undirected conformational sampling after substrate binding.

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