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Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking
Author(s) -
Wenge Ulrike,
Wengel Jesper,
Wagenknecht HansAchim
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204901
Subject(s) - stacking , nucleic acid , dna , electron transfer , bridging (networking) , locked nucleic acid , computer science , chemistry , helix (gastropod) , computational biology , crystallography , stereochemistry , combinatorial chemistry , biochemistry , biology , photochemistry , oligonucleotide , computer network , ecology , organic chemistry , snail
Lock it, but not too much : LNA units (locked or bridging nucleic acids) in LNA:DNA hybrids lead to a negative effect on electron transfer (ET), but they also force the nucleic acid structure in the A‐type double helix, which allows a better base stacking than the normal B‐type and thus positively influences the ET. This result is significant for the design of nucleic acids of molecular electronics.