Enantioselective Aza‐Morita–Baylis–Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes having  C  2 ‐Symmetric Chiral Bis(imidazoline) Ligands | Zendy

Hyodo Kengo | Zendy; Nakamura Shuichi | Zendy; Shibata Norio | Zendy

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Enantioselective Aza‐Morita–Baylis–Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes having C 2 ‐Symmetric Chiral Bis(imidazoline) Ligands

Author(s) -

Hyodo Kengo,

Nakamura Shuichi,

Shibata Norio

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204891

Subject(s) - acrylonitrile , enantioselective synthesis , chemistry , catalysis , palladium , methylene , pincer movement , combinatorial chemistry , baylis–hillman reaction , organic chemistry , polymer , copolymer

Simple and efficient : The first highly enantioselective aza‐Morita–Baylis–Hillman reaction between acrylonitrile and imines has been developed. Excellent yields and enantioselectivities were observed for the reaction of various imines using chiral phebim/Pd II complexes ( 1 ; see scheme). This process offers a simple and efficient route for the synthesis of functionalized α‐methylene‐β‐aminonitriles and their derivatives.

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