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Enantioselective Diels–Alder Reactions with G‐Quadruplex DNA‐Based Catalysts
Author(s) -
Wang Changhao,
Jia Guoqing,
Zhou Jun,
Li Yinghao,
Liu Yan,
Lu Shengmei,
Li Can
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204850
Subject(s) - g quadruplex , enantioselective synthesis , antiparallel (mathematics) , dna , diels–alder reaction , catalysis , chemistry , dna sequencing , combinatorial chemistry , stereochemistry , biochemistry , physics , quantum mechanics , magnetic field
DNA in command : An enantioselective Diels–Alder reaction can be achieved using human telomeric G‐quadruplex DNA‐based catalysts. The absolute configuration of the product can be reversed when the conformation of G‐quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels–Alder reaction were found to be dependent on the DNA sequence.