Premium
Enantioselective H‐Bond‐Directing Approach for Trienamine‐mediated Reactions in Asymmetric Synthesis
Author(s) -
Albrecht Łukasz,
Cruz Acosta Fabio,
Fraile Alberto,
Albrecht Anna,
Christensen Jannie,
Jørgensen Karl Anker
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204790
Subject(s) - enantioselective synthesis , cycloaddition , chemistry , outcome (game theory) , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , mathematics , mathematical economics
Right direction : The presented enantioselective strategy for the preparation of diversely functionalized tetrahydroxanthones is based on a trienamine‐mediated cycloaddition between 2,4‐dieneals and activated chromones. It is possibile to control the stereochemical outcome of such reactions by employing an H‐bond‐directing aminocatalyst.