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Detection of Molecular Chirality by Induced Resonance Raman Optical Activity in Europium Complexes
Author(s) -
Yamamoto Shigeki,
Bouř Petr
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204765
Subject(s) - raman optical activity , europium , chirality (physics) , enantiomer , raman spectroscopy , resonance (particle physics) , enantiomeric excess , chemistry , absolute configuration , analytical chemistry (journal) , nuclear magnetic resonance , stereochemistry , physics , optics , organic chemistry , atomic physics , chiral symmetry , quantum mechanics , ion , enantioselective synthesis , nambu–jona lasinio model , quark , catalysis
Beef up the signal : Induced resonance Raman optical activity (IRROA) in the presence of a europium complex enabled the detection of molecular chirality (see picture) with a 10 4 ‐fold increase in sensitivity relative to that observed with conventional nonresonant vibrational ROA. The method can thus be used as a sensitive tool for the determination of the absolute configuration and enantiomeric excess of organic and biologically relevant compounds.