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Back Cover: Bioinspired Total Synthesis of Agelastatin A (Angew. Chem. Int. Ed. 28/2012)
Author(s) -
Reyes Jeremy Chris P.,
Romo Daniel
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204757
Subject(s) - int , cover (algebra) , ring (chemistry) , total synthesis , pyrrole , natural product , reagent , stereochemistry , chemistry , combinatorial chemistry , computer science , organic chemistry , engineering , mechanical engineering , operating system
Enzymatic Transformations can sometimes be emulated in the laboratory using judiciously chosen reagents and reaction conditions. In their Communication on page 6870 ff., J. C. P. Reyes and D. Romo describe a bioinspired synthetic route to agelastatin A, a unique tetracyclic member of the pyrrole‐2‐aminoimidazole family of alkaloids. The efficiency of the developed route, in which the formation of the C‐ring of the natural product precedes that of the B‐ring, suggests biosynthetic relevance.