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Catalyst‐Controlled Chemoselective Arylation of 2‐Aminobenzimidazoles
Author(s) -
Ueda Satoshi,
Buchwald Stephen L.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204710
Subject(s) - catalysis , azole , combinatorial chemistry , nitrogen , chemoselectivity , chemistry , scheme (mathematics) , organic chemistry , mathematics , biology , antifungal , mathematical analysis , microbiology and biotechnology
What N would you like? The chemoselective and complementary Pd‐ and Cu‐catalyzed N‐arylation of 2‐aminobenzimidazoles is described. Selective N‐arylation of the amino group was achieved with a Pd‐catalyzed method, while selective N‐arylation of azole nitrogen was achieved with a Cu‐catalyzed procedure (see scheme).