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Protein‐Assisted One‐Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells
Author(s) -
Colombo Miriam,
Mazzucchelli Serena,
Collico Veronica,
Avvakumova Svetlana,
Pandolfi Laura,
Corsi Fabio,
Porta Francesca,
Prosperi Davide
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204699
Subject(s) - colloidal gold , nanoparticle , nanotechnology , cancer cell , membrane , materials science , combinatorial chemistry , chemistry , biophysics , cancer , biochemistry , biology , genetics
All bound up : A small variant of protein A (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio‐nanoparticle systems suitable for selective cell labeling by membrane‐receptor‐specific recognition.