Premium
Redox Self‐Sufficient Biocatalyst Network for the Amination of Primary Alcohols
Author(s) -
Sattler Johann H.,
Fuchs Michael,
Tauber Katharina,
Mutti Francesco G.,
Faber Kurt,
Pfeffer Jan,
Haas Thomas,
Kroutil Wolfgang
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204683
Subject(s) - primary (astronomy) , amination , biocatalysis , redox , chemistry , reductive amination , biochemical engineering , computer science , cascade , organic chemistry , polymer science , combinatorial chemistry , engineering , catalysis , chromatography , reaction mechanism , physics , astronomy
Driving the machinery : A biocatalytic redox‐neutral cascade for the preparation of terminal primary amines from primary alcohols at the expense of ammonia has been established in a one‐pot one‐step method (see picture). Applying this artificial biocatalyst network, long‐chain 1,ω‐alkanediols were converted into diamines, which are building blocks for polymers, in up to 99 % conversion.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom