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Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles
Author(s) -
Agostini Alessandro,
Mondragón Laura,
Bernardos Andrea,
MartínezMáñez Ramón,
Marcos M. Dolores,
Sancenón Félix,
Soto Juan,
Costero Ana,
ManguanGarcía Cristina,
Perona Rosario,
MorenoTorres Marta,
AparicioSanchis Rafael,
Murguía José Ramón
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204663
Subject(s) - mesoporous silica , nanoparticle , nanotechnology , intracellular , substrate (aquarium) , chemistry , mesoporous material , computer science , biophysics , materials science , biochemistry , biology , ecology , catalysis
Learning to let go with age : Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto‐oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence‐associated β‐galactosidase (SA‐β‐gal), and releases the cargo upon entry into SA‐β‐gal expressing cells.

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