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Multicomponent Assembly of Highly Substituted Indoles by Dual Palladium‐Catalyzed Coupling Reactions
Author(s) -
Knapp John M.,
Zhu Jie S.,
Tantillo Dean J.,
Kurth Mark J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204633
Subject(s) - palladium , catalysis , alkene , coupling (piping) , coupling reaction , combinatorial chemistry , chemistry , dual (grammatical number) , reaction mechanism , computer science , computational chemistry , organic chemistry , materials science , philosophy , metallurgy , linguistics
Highly substituted indoles were synthesized by a palladium‐catalyzed reaction involving three independent components in a one‐pot reaction. Two distinct palladium‐catalyzed coupling reactions occur with a single catalytic system: a Buchwald‐Hartwig reaction and an arene‐alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.