Multicomponent Assembly of Highly Substituted Indoles by Dual Palladium‐Catalyzed Coupling Reactions | Zendy

Knapp John M. | Zendy; Zhu Jie S. | Zendy; Tantillo Dean J. | Zendy; Kurth Mark J. | Zendy

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Multicomponent Assembly of Highly Substituted Indoles by Dual Palladium‐Catalyzed Coupling Reactions

Author(s) -

Knapp John M.,

Zhu Jie S.,

Tantillo Dean J.,

Kurth Mark J.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204633

Subject(s) - palladium , catalysis , alkene , coupling (piping) , coupling reaction , combinatorial chemistry , chemistry , dual (grammatical number) , reaction mechanism , computer science , computational chemistry , organic chemistry , materials science , philosophy , metallurgy , linguistics

Highly substituted indoles were synthesized by a palladium‐catalyzed reaction involving three independent components in a one‐pot reaction. Two distinct palladium‐catalyzed coupling reactions occur with a single catalytic system: a Buchwald‐Hartwig reaction and an arene‐alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.

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