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Enzymatic Sculpting of Nanoscale and Microscale Surface Topographies
Author(s) -
Huang JenHuang,
Jayaraman Arul,
Ugaz Victor M.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204600
Subject(s) - microscale chemistry , nanoscopic scale , bovine serum albumin , nanotechnology , lithography , polymer , filtration (mathematics) , enzyme , etching (microfabrication) , chemistry , materials science , computer science , chromatography , biochemistry , organic chemistry , mathematics , optoelectronics , mathematics education , statistics , layer (electronics)
Lithography‐free etching of complex surface features is achieved by harnessing the enzyme proteinase K (PK), controlled by bovine serum albumin (BSA), to digest a biodegradable polymer. This bio‐sculpting process is used to construct a membraneless filtration device for the size‐based isolation and enrichment of cells from whole blood.