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Creation of Pure Nanodrugs and Their Anticancer Properties
Author(s) -
Kasai Hitoshi,
Murakami Tatsuya,
Ikuta Yoshikazu,
Koseki Yoshitaka,
Baba Koichi,
Oikawa Hidetoshi,
Nakanishi Hachiro,
Okada Masahiro,
Shoji Mitsuru,
Ueda Minoru,
Imahori Hiroshi,
Hashida Mitsuru
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204596
Subject(s) - camptothecin , irinotecan , anticancer drug , nanoparticle , aqueous solution , chemistry , nanotechnology , sn 38 , derivative (finance) , drug , materials science , pharmacology , cancer , biochemistry , organic chemistry , medicine , colorectal cancer , financial economics , economics
A method for preparing nanoparticles of a water‐insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN‐38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.