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A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells
Author(s) -
Wang Danling,
Wang Jianing,
Bonamy Ghislain M. C.,
Meeusen Shelly,
Brusch Richard G.,
Turk Carolina,
Yang Pengyu,
Schultz Peter G.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204589
Subject(s) - mitochondrial fusion , mitochondrion , microbiology and biotechnology , fragmentation (computing) , fusion , mitochondrial dna , cell fusion , programmed cell death , mitochondrial apoptosis induced channel , chemistry , biology , cell , biophysics , apoptosis , inner mitochondrial membrane , biochemistry , gene , philosophy , ecology , linguistics
Mitochondrial dynamics : An image‐based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial‐fragmentation‐associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture).