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Iridium‐Catalyzed Oxidant‐Free Dehydrogenative CH Bond Functionalization: Selective Preparation of N‐Arylpiperidines through Tandem Hydrogen Transfers
Author(s) -
Yuan Kedong,
Jiang Fan,
Sahli Zeyneb,
Achard Mathieu,
Roisnel Thierry,
Bruneau Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204582
Subject(s) - iridium , tandem , catalysis , chemistry , surface modification , combinatorial chemistry , organic chemistry , materials science , composite material
Relay to the finish : The atom‐economical tandem hydrogen autotransfer catalyzed by iridium(III) has been efficiently applied for the preparation of N‐arylpiperidines starting from easily accessible anilines, diols, and aldehydes (see scheme). This protocol is also compatible with the use of diethyl carbonate as an ecofriendly solvent.