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Cover Picture: Sialyl Lewis x : A “Pre‐Organized Water Oligomer”? (Angew. Chem. Int. Ed. 29/2012)
Author(s) -
Binder Florian P. C.,
Lemme Katrin,
Preston Roland C.,
Ernst Beat
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204559
Subject(s) - oligomer , isothermal titration calorimetry , hydrogen bond , chemistry , cover (algebra) , molecule , int , polymer chemistry , crystallography , polymer science , organic chemistry , computer science , mechanical engineering , engineering , operating system
A surrogate for clustered water molecules attached to a scaffold is how the “pre‐organized water oligomer” sialyl Lewis x can be described. The impetus for its binding to E‐selectin is investigated by B. Ernst et al. in their Communication on page 7327 ff. Using isothermal titration calorimetry they show the key factors are the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit on releasing water molecules from the large binding interface.