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Symbiotic Cooperation in the Biosynthesis of a Phytotoxin
Author(s) -
Scherlach Kirstin,
Busch Benjamin,
Lackner Gerald,
Paszkowski Uta,
Hertweck Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204540
Subject(s) - phytotoxin , biosynthesis , monooxygenase , computational biology , biology , gene , biochemistry , cytochrome p450 , enzyme , toxin
Division of labor : A combination of genetic, microbial, and chemical analyses solved the riddle of the dual epoxidation in the biosynthesis of rhizoxin, the causative agent of rice seedling blight. Bacterial endosymbionts of Rhizopus microsporus mediate the first epoxidation by a dedicated cytochrome P450 monooxygenase. The second oxirane ring is introduced by the fungal host and results in a substantially increased potency of the phytotoxin.