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Facile Synthesis of Sterically Hindered and Electron‐Deficient Secondary Amides from Isocyanates
Author(s) -
Schäfer Gabriel,
Matthey Coraline,
Bode Jeffrey W.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204481
Subject(s) - steric effects , reagent , chemistry , combinatorial chemistry , organic chemistry
The big easy : The direct coupling of Grignard reagents to isocyanates provides a facile and robust solution for the synthesis of sterically hindered and electron‐deficient secondary amides. The products are obtained in high yields without the need for excess reagents or chromatographic purification.