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Intramolecular Alkoxycyanation and Alkoxyacylation Reactions: New Types of Alkene Difunctionalizations for the Construction of Oxygen Heterocycles
Author(s) -
Wolfe John P.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204470
Subject(s) - intramolecular force , alkene , catalysis , chemistry , transition metal , combinatorial chemistry , metal , organic chemistry
Functionalized dihydrobenzofuran derivatives can be obtained by intramolecular alkoxycyanation and alkoxyacylation of alkenes (see scheme). In both transformations, selective activation of an OFG bond is accomplished by using a transition‐metal catalyst. These transformations represent a conceptually new approach to metal‐catalyzed alkene difunctionalization.
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