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Enantioselective Titanium(III)‐Catalyzed Reductive Cyclization of Ketonitriles
Author(s) -
Streuff Jan,
Feurer Markus,
Bichovski Plamen,
Frey Georg,
Gellrich Urs
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204469
Subject(s) - enantioselective synthesis , ketyl , catalysis , nitrile , titanium , chemistry , combinatorial chemistry , organic chemistry , radical
Reduction, please ! The title reaction affords α‐hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa‐titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
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