Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water | Zendy

Staudt Svenja | Zendy; Burda Edyta | Zendy; Giese Carolin | Zendy; Müller Christina A. | Zendy; Marienhagen Jan | Zendy; Schwaneberg Ulrich | Zendy; Hummel Werner | Zendy; Drauz Karlheinz | Zendy; Gröger Harald | Zendy

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Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

Author(s) -

Staudt Svenja,

Burda Edyta,

Giese Carolin,

Müller Christina A.,

Marienhagen Jan,

Schwaneberg Ulrich,

Hummel Werner,

Drauz Karlheinz,

Gröger Harald

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204464

Subject(s) - monooxygenase , chemistry , cofactor , solvent , oxygen , catalysis , alcohol dehydrogenase , molecular oxygen , organic chemistry , enzyme , photochemistry , cytochrome p450

It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP + (and a little 2‐propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).

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