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Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water
Author(s) -
Staudt Svenja,
Burda Edyta,
Giese Carolin,
Müller Christina A.,
Marienhagen Jan,
Schwaneberg Ulrich,
Hummel Werner,
Drauz Karlheinz,
Gröger Harald
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204464
Subject(s) - monooxygenase , chemistry , cofactor , solvent , oxygen , catalysis , alcohol dehydrogenase , molecular oxygen , organic chemistry , enzyme , photochemistry , cytochrome p450
It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP + (and a little 2‐propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).