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Enantioselective Hydrogenation of α‐Substituted Acrylic Acids Catalyzed by Iridium Complexes with Chiral Spiro Aminophosphine Ligands
Author(s) -
Zhu ShouFei,
Yu YanBo,
Li Shen,
Wang LiXin,
Zhou QiLin
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204363
Subject(s) - iridium , enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , asymmetric hydrogenation , organic chemistry
Highly active : Iridium complexes with chiral spiro aminophosphine ligands were synthesized and applied as catalysts for the asymmetric hydrogenation of α‐substituted acrylic acids (see scheme). The complexes were highly active catalysts, showing turnover frequencies of up to 6000 h −1 , and catalyst loadings could be reduced to 0.01 mol %.