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Metal Carbonyl–Gold Nanoparticle Conjugates for Live‐Cell SERS Imaging
Author(s) -
Kong Kien Voon,
Lam Zhiyong,
Goh Wenda Douglas,
Leong Weng Kee,
Olivo Malini
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204349
Subject(s) - osmium , surface modification , colloidal gold , metal carbonyl , conjugate , nanoparticle , nanotechnology , chemistry , surface enhanced raman spectroscopy , raman spectroscopy , combinatorial chemistry , aqueous solution , metal , materials science , photochemistry , ruthenium , organic chemistry , catalysis , raman scattering , mathematical analysis , physics , mathematics , optics
Conjugates of organometallic osmium carbonyl clusters and gold nanoparticles (see picture) show a strong carbonyl signal in surface‐enhanced Raman spectroscopy. The ease of bio‐functionalization and the high stability and good dispersibility in aqueous solution make these conjugates excellent candidates for biomedical applications, as demonstrated by live‐cell imaging with the carbonyl signals of OM‐NP(PEG)‐L conjugates.