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Incorporation of Penicillin‐Producing Fungi into Living Materials to Provide Chemically Active and Antibiotic‐Releasing Surfaces
Author(s) -
Gerber Lukas C.,
Koehler Fabian M.,
Grass Robert N.,
Stark Wendelin J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204337
Subject(s) - penicillium chrysogenum , penicillin , bacteria , antibiotics , microbiology and biotechnology , food science , biology , genetics
Living materials : Artificial biological niches are loaded with the penicillin‐producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on‐site. No reloading of the active compound is needed. Gram‐positive bacteria were efficiently killed if nearby, whereas Gram‐negative bacteria (control experiment, not sensitive to penicillin) were not affected.