Convergent Solid‐Phase Synthesis of N‐Glycopeptides Facilitated by Pseudoprolines at Consensus‐Sequence Ser/Thr Residues | Zendy

Ullmann Vera | Zendy; Rädisch Marisa | Zendy; Boos Irene | Zendy; Freund Jutta | Zendy; Pöhner Claudia | Zendy; Schwarzinger Stefan | Zendy; Unverzagt Carlo | Zendy

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Convergent Solid‐Phase Synthesis of N‐Glycopeptides Facilitated by Pseudoprolines at Consensus‐Sequence Ser/Thr Residues

Author(s) -

Ullmann Vera,

Rädisch Marisa,

Boos Irene,

Freund Jutta,

Pöhner Claudia,

Schwarzinger Stefan,

Unverzagt Carlo

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204272

Subject(s) - glycopeptide , joins , sequence (biology) , glycan , computer science , peptide , consensus sequence , glycoprotein , computational biology , chemistry , combinatorial chemistry , biochemistry , information retrieval , biology , peptide sequence , programming language , gene , antibiotics

Remote control : The formation of aspartimides is greatly decreased during peptide elongation and during convergent sugar couplings of Asp‐X‐Ser/Thr peptides that contain a pseudoproline (red; see scheme). The robust approach efficiently joins complex peptides and N‐glycans on the solid phase thus facilitating the availability of glycopeptides and glycoproteins.

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