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Convergent Solid‐Phase Synthesis of N‐Glycopeptides Facilitated by Pseudoprolines at Consensus‐Sequence Ser/Thr Residues
Author(s) -
Ullmann Vera,
Rädisch Marisa,
Boos Irene,
Freund Jutta,
Pöhner Claudia,
Schwarzinger Stefan,
Unverzagt Carlo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204272
Subject(s) - glycopeptide , joins , sequence (biology) , glycan , computer science , peptide , consensus sequence , glycoprotein , computational biology , chemistry , combinatorial chemistry , biochemistry , information retrieval , biology , peptide sequence , programming language , gene , antibiotics
Remote control : The formation of aspartimides is greatly decreased during peptide elongation and during convergent sugar couplings of Asp‐X‐Ser/Thr peptides that contain a pseudoproline (red; see scheme). The robust approach efficiently joins complex peptides and N‐glycans on the solid phase thus facilitating the availability of glycopeptides and glycoproteins.