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Charge‐Balanced Metal Fluoride Complexes for Protein Kinase A with Adenosine Diphosphate and Substrate Peptide SP20
Author(s) -
Jin Yi,
Cliff Matthew J.,
Baxter Nicola J.,
Dannatt Hugh R. W.,
Hounslow Andrea M.,
Bowler Matthew W.,
Blackburn G. Michael,
Waltho Jonathan P.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204266
Subject(s) - substrate (aquarium) , cyan , peptide , chemistry , metal , adenosine , fluoride , inorganic chemistry , biochemistry , organic chemistry , physics , biology , ecology , optics
Well‐balanced : 19 F NMR spectroscopy defined a trifluoromagnesate complex for protein kinase A (multicolored) with adenosine diphosphate (black), the MgF 3 − ion (green), and the SP20 peptide substrate (purple with dots). A sphere (cyan) centered on the MgF 3 − ion embraces all catalytic components and much of the SP20 substrate. The content of the sphere is uncharged conforming to the charge balance hypothesis.