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Expeditious Synthesis of Tetrasubstituted Helical Alkenes by a Cascade of Palladium‐Catalyzed CH Activations
Author(s) -
Liu Hongqiang,
ElSalfiti Mohamed,
Lautens Mark
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204226
Subject(s) - palladium , domino , norbornene , cascade reaction , catalysis , intermolecular force , chemistry , cascade , molecule , combinatorial chemistry , stereochemistry , sequence (biology) , organic chemistry , biochemistry , monomer , chromatography , polymer
Twisted molecules : A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium‐catalyzed norbornene‐mediated domino reaction is presented. This intermolecular domino process allows the formation of three CC bonds in one operation through a CH activation/carbopalladation/CH activation sequence.