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α‐Amination of Aldehydes Catalyzed by In Situ Generated Hypoiodite
Author(s) -
Tian JieSheng,
Ng Kang Wai Jeffrey,
Wong JiunRu,
Loh TeckPeng
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204215
Subject(s) - scope (computer science) , amination , chemistry , catalysis , combinatorial chemistry , substrate (aquarium) , organic chemistry , computer science , oceanography , programming language , geology
The metal‐free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co‐oxidant. This approach has several advantages: it is a metal‐free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by‐products from the co‐oxidant that is used.