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From One‐Photon to Two‐Photon Probes: “Caged” Compounds, Actuators, and Photoswitches
Author(s) -
Bort Guillaume,
Gallavardin Thibault,
Ogden David,
Dalko Peter I.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204203
Subject(s) - two photon excitation microscopy , photon , nanotechnology , excitation , laser , computer science , physics , biophysics , optics , materials science , biology , quantum mechanics
Abstract Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two‐photon excitation has significant advantages deep in biological tissues, but raises problems in the design of “smart” probes compatible with cell physiology. This Review discusses the chemical challenges in generating suitable two‐photon probes.