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Encapsulation of Biomacromolecules within Polymersomes by Electroporation
Author(s) -
Wang Linge,
Chierico Luca,
Little Daniel,
Patikarnmonthon Nisa,
Yang Zhou,
Azzouz Mimoun,
Madsen Jeppe,
Armes Steven P.,
Battaglia Giuseppe
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204169
Subject(s) - polymersome , electroporation , vesicle , chemistry , membrane , nanotechnology , biophysics , microbiology and biotechnology , materials science , biology , biochemistry , copolymer , polymer , amphiphile , organic chemistry , gene
Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.