Investigation of RNA–Ligand Interactions by  19 F NMR Spectroscopy Using Fluorinated Probes | Zendy

Lombès Thomas | Zendy; Moumné Roba | Zendy; Larue Valéry | Zendy; Prost Elise | Zendy; Catala Marjorie | Zendy; Lecourt Thomas | Zendy; Dardel Frédéric | Zendy; Micouin Laurent | Zendy; Tisné Carine | Zendy

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Investigation of RNA–Ligand Interactions by 19 F NMR Spectroscopy Using Fluorinated Probes

Author(s) -

Lombès Thomas,

Moumné Roba,

Larue Valéry,

Prost Elise,

Catala Marjorie,

Lecourt Thomas,

Dardel Frédéric,

Micouin Laurent,

Tisné Carine

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201204083

Subject(s) - riboswitch , swap (finance) , nuclear magnetic resonance spectroscopy , ligand (biochemistry) , chemistry , rna , spectroscopy , visualization , computer science , physics , stereochemistry , biochemistry , data mining , non coding rna , gene , receptor , finance , quantum mechanics , economics

Spy swap : The interaction between an unlabeled RNA and unlabeled ligands (red hexagon) can be monitored by 19 F NMR spectroscopy using small fluorinated diamines (green star) as spy reporters (see scheme). This technique also enables the visualization of the conformational capture of a riboswitch by its ligand.

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