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β‐Lactones through Catalytic Asymmetric Heterodimerization of Ketenes
Author(s) -
MarquésLópez Eugenia,
Christmann Mathias
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204026
Subject(s) - ketene , chemistry , catalysis , acceptor , combinatorial chemistry , medicinal chemistry , organic chemistry , physics , condensed matter physics
Simple, but effective : The asymmetric heterodimerization of two different ketenes (see scheme) has been developed 65 years after the first seminal studies on ketene dimerization. The key to sufficiently suppressing the competing homodimerization of the monosubstituted ketene donor (shown in blue) is its slow addition to the disubstituted acceptor (shown in red).