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DNA Self‐Assembly of Targeted Near‐Infrared‐Responsive Gold Nanoparticles for Cancer Thermo‐Chemotherapy
Author(s) -
Xiao Zeyu,
Ji Changwei,
Shi Jinjun,
Pridgen Eric M.,
Frieder Jillian,
Wu Jun,
Farokhzad Omid C.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201204018
Subject(s) - polyethylene glycol , dna , peg ratio , nanotechnology , in vivo , colloidal gold , in vitro , nanoparticle , cancer therapy , materials science , cancer , cancer research , chemistry , medicine , biochemistry , biology , genetics , finance , economics
Targeted cancer therapy : Inspired by the ability of DNA hybridization, a targeted near‐infrared (NIR) light‐responsive delivery system has been developed through simple DNA self‐assembly (see picture; PEG=polyethylene glycol). This DNA‐based platform shows the ability of releasing therapeutics upon near‐infrared irradiation, and remarkable targeted thermo‐ and chemotherapeutic efficacy in vitro and in vivo.