Premium
Chemoselective N‐Acylation of Indoles and Oxazolidinones with Carbonylazoles
Author(s) -
Heller Stephen T.,
Schultz Erica E.,
Sarpong Richmond
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203976
Subject(s) - acylation , reactivity (psychology) , amine gas treating , alcohol , chemistry , chemoselectivity , organic chemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
Unique reactivity : In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N‐acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU).