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Concise Synthesis of Acetal‐Protected syn 1,3‐Diols by a Tandem Hemiacetal Formation/Tsuji–Trost Reaction
Author(s) -
Wang Liang,
Menche Dirk
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203911
Subject(s) - hemiacetal , acetal , polyketide , domino , stereochemistry , polyol , diol , chemistry , tandem , computer science , organic chemistry , catalysis , engineering , biosynthesis , enzyme , polyurethane , aerospace engineering
Designed, developed, and applied : A novel domino sequence was used for the rapid assembly of acetal‐protected syn 1,3‐diols. The convergent synthesis of a polyol fragment of the macrolide antibiotic RK‐397 demonstrates that this method is suitable for the rapid and stereoselective preparation of polyketide‐type diol motifs.