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Catalytic Enantioselective Synthesis of Secondary Alkylboronate Building Blocks With and Without Metals
Author(s) -
Bull James A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203876
Subject(s) - enantioselective synthesis , catalysis , iridium , conjugate , chemistry , combinatorial chemistry , carbon fibers , ideal (ethics) , metal , materials science , organic chemistry , mathematics , composite material , mathematical analysis , composite number , philosophy , epistemology
With or without you : Chiral secondary alkylboronates can now be accessed by highly enantioselective catalytic methods including conjugate addition under metal‐free conditions with an NHC catalyst, and also iridium‐catalyzed hydrogenation. These methods reinforce the potential of secondary alkylboronates as ideal and universal chiral building blocks for bond formation to sp 3 carbon atoms.