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Programmable Magnetic Tweezers and Droplet Microfluidic Device for High‐Throughput Nanoliter Multi‐Step Assays
Author(s) -
AliCherif Anaïs,
Begolo Stefano,
Descroix Stéphanie,
Viovy JeanLouis,
Malaquin Laurent
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203862
Subject(s) - microfluidics , multiplexing , tweezers , computer science , nanotechnology , matching (statistics) , throughput , magnetic nanoparticles , mixing (physics) , off the shelf , computer hardware , optical tweezers , chemistry , materials science , physics , nanoparticle , medicine , telecommunications , software engineering , pathology , quantum mechanics , wireless
Tweezing out the answer : A microfluidic device combining droplets (less than 100 nL) and magnetic particles (see scheme) was implemented for fast heterogeneous multiplexed assays. Magnetic tweezers can perform the manipulations required in an immunoassay (capture, extraction, mixing, and rinsing). This method was applied to the diagnosis of congenital hypothyroidism with 14 p M sensitivity.