Premium
Selective Rhodium(III)‐Catalyzed Cross‐Dehydrogenative Coupling of Furan and Thiophene Derivatives
Author(s) -
Kuhl Nadine,
Hopkinson Matthew N.,
Glorius Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203792
Subject(s) - thiophene , rhodium , furan , catalysis , chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , metallurgy
A hot couple : An unprecedented rhodium(III)‐catalyzed cross‐dehydrogenative coupling (CDC) of various furan and thiophene derivatives leads to valuable 2,2′‐bi(heteroaryl) products in good yields and selectivities (see scheme). In addition, pyrroles and indoles can also be used as coupling partners, giving C3‐arylated products.