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Ceria Nanoparticles that can Protect against Ischemic Stroke
Author(s) -
Kim Chi Kyung,
Kim Taeho,
Choi InYoung,
Soh Min,
Kim Dohoung,
Kim YoungJu,
Jang Hyunduk,
Yang HyeSung,
Kim Jun Yup,
Park HongKyun,
Park Seung Pyo,
Park Sangseung,
Yu Taekyung,
Yoon ByungWoo,
Lee SeungHoon,
Hyeon Taeghwan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203780
Subject(s) - reactive oxygen species , nanoparticle , apoptosis , in vivo , programmed cell death , in vitro , stroke (engine) , ischemic stroke , oxygen , materials science , nanotechnology , biophysics , chemistry , medicine , ischemia , biochemistry , biology , microbiology and biotechnology , organic chemistry , mechanical engineering , engineering
Uniform 3 nm‐sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS‐induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.