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Isotope‐Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
Author(s) -
Brandmayr Caterina,
Wagner Mirko,
Brückl Tobias,
Globisch Daniel,
Pearson David,
Kneuttinger Andrea Christa,
Reiter Veronika,
Hienzsch Antje,
Koch Susanne,
Thoma Ines,
Thumbs Peter,
Michalakis Stylianos,
Müller Markus,
Biel Martin,
Carell Thomas
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203769
Subject(s) - transfer rna , translational efficiency , posttranslational modification , chemistry , nucleobase , protein biosynthesis , surface modification , in vitro , biochemistry , rna , translation (biology) , enzyme , messenger rna , dna , gene
Useful diversity : Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue‐specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue‐specific translational efficiency.