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A Multicolor Nanoprobe for Detection and Imaging of Tumor‐Related mRNAs in Living Cells
Author(s) -
Li Na,
Chang Chenyang,
Pan Wei,
Tang Bo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203767
Subject(s) - nanoprobe , tumor cells , messenger rna , computer science , computational biology , biology , cancer research , gene , nanotechnology , genetics , materials science , nanoparticle
Multidetector : A novel nanoprobe, based on multicolor nanoflares, for the simultaneous detection and imaging of three tumor‐related mRNAs in living cells has been developed. The nanoprobe possesses high specificity, nuclease stability, and good biocompatibility. It can also effectively distinguish cancer cells from normal cells and identify changes in the levels of mRNA expression.