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Tracking Bisphosphonates through a 20 mm Thick Porcine Tissue by Using Surface‐Enhanced Spatially Offset Raman Spectroscopy
Author(s) -
Xie Hainan,
Stevenson Ross,
Stone Nicholas,
HernandezSantana Aaron,
Faulds Karen,
Graham Duncan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203728
Subject(s) - raman spectroscopy , materials science , raman scattering , biomedical engineering , spectroscopy , offset (computer science) , optics , medicine , computer science , physics , quantum mechanics , programming language
Track it down : A recognized surface‐enhanced Raman scattering (SERS) nanotag signal was monitored from a thin, dispersed layer of bisphosphonate‐functionalized nanotags on a bone sample, through a 20 mm thick specimen of porcine muscle tissue by surface‐enhanced spatial offset Raman spectroscopy (SESORS; see picture). The result demonstrates the great potential for non‐invasive in vivo bisphosphonate drug tracking.