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Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA
Author(s) -
Cornett Evan M.,
Campbell Eleanor A.,
Gulenay George,
Peterson Evan,
Bhaskar Neha,
Kolpashchikov Dmitry M.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203708
Subject(s) - multiplex , mycobacterium tuberculosis , dna , virology , multiplex polymerase chain reaction , biology , tuberculosis , microbiology and biotechnology , genetics , polymerase chain reaction , medicine , gene , pathology
Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild‐type and rifampin‐resistant (Rif r ) Mycobacterium tuberculosis ( Mtb ) in a multiplex real‐time fluorescent assay.