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Synthesis of Indoles through Highly Efficient Cascade Reactions of Sulfur Ylides and N ‐( ortho ‐Chloromethyl)aryl Amides
Author(s) -
Yang QingQing,
Xiao Cong,
Lu LiangQiu,
An Jing,
Tan Fen,
Li BinJie,
Xiao WenJing
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203657
Subject(s) - cascade , aryl , sulfur , chemistry , cascade reaction , combinatorial chemistry , organic chemistry , ylide , reaction conditions , catalysis , alkyl , chromatography
Batting the ylides : A simple procedure carried out under mild conditions allows the direct and efficient synthesis of structurally diverse indoles. This approach involves a cascade reaction of sulfur ylides and N ‐( ortho ‐chloromethyl)aryl amides (see scheme).