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A Polycomponent Metal‐Catalyzed Aliphatic, Allylic, and Benzylic Fluorination
Author(s) -
Bloom Steven,
Pitts Cody Ross,
Miller David Curtin,
Haselton Nathan,
Holl Maxwell Gargiulo,
Urheim Ellen,
Lectka Thomas
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203642
Subject(s) - catalysis , selectfluor , allylic rearrangement , alkane , chemistry , organic chemistry , imine , combinatorial chemistry , substrate (aquarium) , metal , oceanography , geology
A group effort : Reported is the title reaction using a polycomponent catalytic system involving commercially available Selectfluor, a putative radical precursor N ‐hydroxyphthalimide, an anionic phase‐transfer catalyst (KB(C 6 F 5 ) 4 ), and a copper(I) bis(imine). The catalyst system formed leads to monofluorinated compounds selectively (see example) without the necessity for an excess of the alkane substrate.